Potassium Carbonate → HCID 178440916、化合物

HRID 45941

反応式

HRID 45941 の反応式
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[NH:3][CH:2]=1.[C:11]([C:15]1[CH:22]=[CH:21][C:18]([CH2:19]Br)=[CH:17][CH:16]=1)([CH3:14])([CH3:13])[CH3:12].C([O-])([O-])=O.[K+].[K+]>>[C:11]([C:15]1[CH:22]=[CH:21][C:18]([CH2:19][N:10]([CH2:19][C:18]2[CH:21]=[CH:22][C:15]([C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:16][CH:17]=2)[C:8]2[CH:7]=[CH:6][C:5]3[NH:1][CH:2]=[N:3][C:4]=3[CH:9]=2)=[CH:17][CH:16]=1)([CH3:14])([CH3:13])[CH3:12]

参加物

4

反応物 3

HCID 11430Potassium CarbonateHCID 136235-AminobenzimidazoleHCID 878361-(Bromomethyl)-4-(1,1-dimethylethyl)benzene

生成物 1

HCID 178440916HCID 178440916、化合物

実験手順

The compound was synthesized starting from benzimidazol-5-amine (133 mg; 1 mmol; 1 eq.), 4-tert-butylbenzylbromide (500 mg; 2.2 mmol; 2.2 eq.) and K2CO3 (304 mg; 2.2 mmol; 2.2 eq.) according to method 5; Yield: 0.250 g (58.7%); MS m/z: 426.3 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 1.24 (s, 18H); 4.62 (s, 4H); 6.69 (br s, 1H); 6.74 (dd, 1H, 4J=2.1 Hz, 3J=8.9 Hz); 7.17-7.22 (m, 4H); 7.31-7.33 (m, 5H); 7.94 (s, 1H); 11.89 (br s, 1H); HPLC (METHOD [A]): rt 20.49 min (86.5%)

後処理

  1. customThe compound was synthesized
  2. customrt 20.49 min (86.5%)

出典と根拠

ORDレコード
ord-23754573f920462a9a0c78191ced1446
出典データセット
uspto-grants-2013_09
特許番号
US08541596B2

関連ノート

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