Methyl 3-chloro-4-fluoro-alpha-azidocinnamate → Methyl 5-chloro-6-fluoro-1H-indole-2-carboxylate

HRID 459459ノート

反応式

HRID 459459 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][C:16]=1[F:17])[CH:5]=[C:6]([N:11]=[N+]=[N-])[C:7]([O:9][CH3:10])=[O:8]>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:14](=[CH:15][C:16]=1[F:17])[NH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5]2

参加物

3

反応物 1

HCID 54554773Methyl 3-chloro-4-fluoro-alpha-azidocinnamate

生成物 1

HCID 18986230Methyl 5-chloro-6-fluoro-1H-indole-2-carboxylate

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A mixture of methyl 3-chloro-4-fluoro-α-azidocinnamate (Japanese Patent Application Laid-Open No. 149723/1995) (1.85 g) and xylene (140 ml) was heated under reflux for 1 hour, and the solvent was then distilled off. The residue was purified by column chromatography on silica gel (dichloromethane) to obtain the title compound (491 mg) as colorless powder.

後処理

  1. temperatureunder reflux for 1 hour
  2. distillationthe solvent was then distilled off
  3. customThe residue was purified by column chromatography on silica gel (dichloromethane)

出典と根拠

ORDレコード
ord-9219bfba367a4a4f9fe7313f3d52e2b0
出典データセット
uspto-grants-2007_03
特許番号
US07192968B2

反応ノート

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