Hydrochloric Acid → (+/-)-trans-N-[(5-Chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine hydrochloride

HRID 459473ノート

反応式

HRID 459473 の反応式
C(O)C.Cl.C(OC([NH:12][C@@H:13]1[CH2:18][CH2:17][CH2:16][CH2:15][C@H:14]1[NH:19][C:20]([C:22]1[NH:23][C:24]2[C:29]([CH:30]=1)=[CH:28][C:27]([Cl:31])=[CH:26][CH:25]=2)=[O:21])=O)(C)(C)C>ClCCl>[ClH:31].[Cl:31][C:27]1[CH:28]=[C:29]2[C:24](=[CH:25][CH:26]=1)[NH:23][C:22]([C:20]([NH:19][C@@H:14]1[CH2:15][CH2:16][CH2:17][CH2:18][C@H:13]1[NH2:12])=[O:21])=[CH:30]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 68910309(+/-)-trans-N1-(tert-Butoxycarbonyl)-N2-[(5-chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine

生成物 1

HCID 18442870(+/-)-trans-N-[(5-Chloroindol-2-yl)carbonyl]-1,2-cyclohexanediamine hydrochloride収率 198.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A saturated ethanol solution (100 ml) of hydrochloric acid was added to a solution of (±)-trans-N1-(tert-butoxycarbonyl)-N2-[(5-chloroindol-2-yl)-carbonyl]-1,2-cyclohexanediamine (5.18 g) in dichloromethane (100 ml) at room temperature. After stirring for 2 days, the reaction mixture was concentrated under reduced pressure, diethyl ether (300 ml) was added to the resultant residue, and colorless precipitate formed was collected by filtration and dried to obtain the title compound (4.30 g) as a colorless solid.

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure, diethyl ether (300 ml)
  2. additionwas added to the resultant residue, and colorless precipitate
  3. customformed
  4. filtrationwas collected by filtration
  5. customdried

出典と根拠

ORDレコード
ord-cbf29c6d023345f1ac021a1cdbfe2508
出典データセット
uspto-grants-2007_03
特許番号
US07192968B2

反応ノート

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