Potassium Carbonate → HCID 178425128、化合物

HRID 45949

反応式

HRID 45949 の反応式
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[NH:3][CH:2]=1.[F:11][C:12]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:13]=1[CH2:14]Br.C([O-])([O-])=O.[K+].[K+]>>[F:11][C:12]1[C:19]([CH3:20])=[CH:18][CH:17]=[CH:16][C:13]=1[CH2:14][N:10]([CH2:14][C:13]1[CH:16]=[CH:17][CH:18]=[C:19]([CH3:20])[C:12]=1[F:11])[C:8]1[CH:7]=[CH:6][C:5]2[NH:1][CH:2]=[N:3][C:4]=2[CH:9]=1

参加物

4

反応物 3

HCID 11430Potassium CarbonateHCID 136235-AminobenzimidazoleHCID 519062Benzene, 1-(bromomethyl)-2-fluoro-3-methyl-

生成物 1

HCID 178425128HCID 178425128、化合物

実験手順

The compound was synthesized starting from benzimidazol-5-amine (133 mg; 1 mmol; 1 eq.), 2-fluoro-3-methylbenzylbromide (447 mg; 2.2 mmol; 2.2 eq.) and K2CO3 (304 mg; 2.2 mmol; 2.2 eq.) according to method 5; Yield: 0.072 g (19.1%); MS m/z: 378.1 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 2.24 (d, 6H, 4JH,F=1.5 Hz); 4.71 (s, 4H); 6.67-6.69 (m, 2H); 6.98 (t, 2H, 3J=7.5 Hz); 7.03-7.06 (m, 2H); 7.13-7.15 (m, 2H), 7.33-7.35 (m, 1H); 7.92 (s, 1H); 11.95 (br s, 1H); HPLC (METHOD [A]): rt 17.77 min (83.5%)

後処理

  1. customThe compound was synthesized
  2. customrt 17.77 min (83.5%)

出典と根拠

ORDレコード
ord-0811b89b739542fcadd2a0bd3390a44d
出典データセット
uspto-grants-2013_09
特許番号
US08541596B2

関連ノート

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