p-Xylyl bromide → HCID 178436363、化合物

HRID 45957

反応式

HRID 45957 の反応式
[CH2:1]([C:3]1[CH:19]=[CH:18][C:6]([CH2:7][NH:8][C:9]2[CH:17]=[CH:16][C:12]3[N:13]=[CH:14][NH:15][C:11]=3[CH:10]=2)=[CH:5][CH:4]=1)[CH3:2].[CH3:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25]Br)=[CH:23][CH:22]=1.C([O-])([O-])=O.[K+].[K+]>>[CH2:1]([C:3]1[CH:19]=[CH:18][C:6]([CH2:7][N:8]([CH2:20][C:21]2[CH:28]=[CH:27][C:24]([CH3:25])=[CH:23][CH:22]=2)[C:9]2[CH:17]=[CH:16][C:12]3[NH:13][CH:14]=[N:15][C:11]=3[CH:10]=2)=[CH:5][CH:4]=1)[CH3:2]

参加物

4

反応物 3

HCID 7721p-Xylyl bromideHCID 11430Potassium CarbonateHCID 67443948N-(4-Ethylbenzyl)-1H-benzo[d]imidazol-5-amine

生成物 1

HCID 178436363HCID 178436363、化合物

実験手順

The compound was synthesized starting from N-(4-ethylbenzyl)benzimidazol-5-amine (251 mg; 1 mmol; 1 eq.), 4-methylbenzylbromide (204 mg; 1.1 mmol; 1.1 eq.) and K2CO3 (152 mg; 1.1 mmol; 1.1 eq.) according to method 6; Yield: 0.131 g (36.9%); MS m/z: 356.5 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 1.14 (t, 3H, 3J=7.6 Hz); 2.25 (s, 3H); 2.55 (q, 2H, 3J=7.6 Hz); 4.60 (s, 4H); 6.68 (br s, 1H); 6.72 (dd, 1H, 4J=1.8 Hz, 3J=8.9 Hz); 7.09-7.19 (m, 8H); 7.32 (d, 1H, 3J=8.9 Hz); 7.89 (s, 1H); 11.88 (br s, 1H); HPLC (METHOD [A]): rt 18.62 min (100%)

後処理

  1. customThe compound was synthesized
  2. customrt 18.62 min (100%)

出典と根拠

ORDレコード
ord-83534f1344dd4b949d27294816ba1012
出典データセット
uspto-grants-2013_09
特許番号
US08541596B2

関連ノート

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