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Pyrazinamide → Isoniazid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrazinamide | HCID 1046 | — |
| 反応物 | (+)-Lactose | HCID 440995 | — |
| 反応物 | (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol;hydrochloride | HCID 16051971 | — |
| 反応物 | Rifampicin | HCID 135398735 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Isoniazid | HCID 3767 | — |
反応手順
Pass Pyrazinamide, Ethambutol Hydrochloride, Rifampicin and Lactose through a sieve and granulate with Starch Paste prepared in Purified Water. Pass the wet mass through multimill and dry the granules at 50–60° C. Pass the dried granules through sieve of mesh size 16. Pass Magnesium Stearate, Purified Talc and Sodium Starch Glycollate through sieve of mesh size 60 and mix with dried granules and isoniazid delayed release powder. Compress the blend into tablets.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07195769B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-5e15d77afc0e48bba66338ba929a252c |
| 出典メモ | uspto-grants-2007_03 |