Pyrazinamide → Isoniazid

HRID 459739

反応式

HRID 459739 の反応式
N1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7](N)=O.CC[C@H](NCCN[C@H]([CH2:22][OH:23])CC)CO.Cl.CC1C2O[C@]3(C)OC=C[C@H](OC)[C@@H](C)[C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)C=CC=C(C)C(NC4C(/C=[N:61]/[N:62]5CCN(C)CC5)=C(O)C(C=2C3=O)=C(C=4O)C=1O)=O.OC1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O>O>[CH:6]1[C:7]([C:22]([NH:61][NH2:62])=[O:23])=[CH:2][CH:3]=[N:4][CH:5]=1

参加物

6

反応物 4

HCID 1046PyrazinamideHCID 440995(+)-LactoseHCID 16051971(2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol;hydrochlorideHCID 135398735Rifampicin

生成物 1

HCID 3767Isoniazid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Pass Pyrazinamide, Ethambutol Hydrochloride, Rifampicin and Lactose through a sieve and granulate with Starch Paste prepared in Purified Water. Pass the wet mass through multimill and dry the granules at 50–60° C. Pass the dried granules through sieve of mesh size 16. Pass Magnesium Stearate, Purified Talc and Sodium Starch Glycollate through sieve of mesh size 60 and mix with dried granules and isoniazid delayed release powder. Compress the blend into tablets.

後処理

  1. customPass the wet mass through multimill and dry the granules at 50–60° C
  2. customPass Magnesium Stearate, Purified Talc and Sodium Starch Glycollate through sieve of mesh size 60
  3. additionmix with dried granules and isoniazid delayed release powder

出典と根拠

ORDレコード
ord-5e15d77afc0e48bba66338ba929a252c
出典データセット
uspto-grants-2007_03
特許番号
US07195769B2

関連ノート

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