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1-(4-Fluorophenyl)piperazine → Methyl {8-fluoro-2-[4-(4-fluorophenyl)-1-piperazinyl]-3-[6-methoxy-3-chlorophenyl]-3,4-dihydro-4-quinazolinyl}acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(4-Fluorophenyl)piperazine | HCID 75260 | — |
| 反応物 | 4-Chloro-2-isocyanato-1-methoxybenzene | HCID 144009 | — |
| 反応物 | Methyl (2E)-3-{3-fluoro-2-[(triphenylphosphoranylidene)amino]phenyl}propenoate | HCID 11983908 | — |
| 生成物 | Methyl {8-fluoro-2-[4-(4-fluorophenyl)-1-piperazinyl]-3-[6-methoxy-3-chlorophenyl]-3,4-dihydro-4-quinazolinyl}acetate | HCID 58824015 | — |
反応手順
Starting with 1.0 g (2.2 mmol) of the iminophosphorane from Example 10A, 423 mg (2.31 mmol) of 2-methoxy-5-chlorophenyl isocyanate and 396 mg (2.2 mmol) of 4-fluorophenylpiperazine, 621 mg (52% of theory) of product are obtained after purification by preparative HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07196086B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-8e79e24a26fd4347a943b758c2a6e265 |
| 出典メモ | uspto-grants-2007_03 |