p-Fluoronitrobenzene → rel-(2R,5S)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine

HRID 459853

反応式

HRID 459853 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[CH3:11][C@H:12]1[CH2:17][NH:16][C@H:15]([CH3:18])[CH2:14][NH:13]1>CN1C(=O)CCC1>[CH3:11][C@H:12]1[CH2:17][NH:16][C@H:15]([CH3:18])[CH2:14][N:13]1[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 9590p-FluoronitrobenzeneHCID 2206722,5-Dimethylpiperazine, trans-

生成物 1

HCID 57664370rel-(2R,5S)-2,5-Dimethyl-1-(4-nitrophenyl)piperazine

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

An NMP solution of fluoro-4-nitrobenzene and (±)-trans-2,5-dimethylpiperazine was stirred at an oil bath temperature of 120° C. for 3 hours to obtain (±)-trans-2,5-dimethyl-1-(4-nitrophenyl)piperazine, which was further treated in a similar manner to Example 4 to obtain an objective compound.

出典と根拠

ORDレコード
ord-eefa40e2896a40478a7d6d15383254f5
出典データセット
uspto-grants-2007_03
特許番号
US07196080B2

関連ノート

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