O=[C:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][CH:10]=2)[CH2:4][CH2:3]1.[C:18]1([CH2:24][CH2:25][CH2:26][NH2:27])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.C(O)(=O)C>C(Cl)Cl>[C:18]1([CH2:24][CH2:25][CH2:26][NH:27][CH:2]2[CH2:7][CH2:6][CH:5]([O:8][C:9]3[CH:17]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][CH:10]=3)[CH2:4][CH2:3]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1Combine 4-(4-oxo-cyclohexyloxy)-benzamide (20 mg, 0.085 mmol), 3-phenyl-propylamine (11 mg, 0.085 mmol), triacetoxyborohydride (23 mg, 0.111 mmol) and acetic acid (5 μL, 0.085 mmol) in CH2Cl2 (1 mL). Let stir overnight. Purify by SCX column (ammonia in methanol 2.0M). Triturate the residue with EtOAc/hexanes 1/1 to provide a white powder (25 mg, 86%).
読み込み中…