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HRID 460016作成日：2026年10月26日
Triethyl phosphite → Diethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methylphosphonate
https://huagongshe.com/reaction/460016
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethyl phosphite | HCID 31215 | — |
| 反応物 | 5-(Bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole | HCID 2794629 | — |
| 生成物 | Diethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methylphosphonate | HCID 86592483 | — |
反応手順
A mixture of 5-(bromomethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (intermediate 3, 1.48 g) and triethylphosphite (1.5 ml) was heated under nitrogen at 150° C. for 1 hour. The mixture was allowed to cool and excess triethylphosphite was removed under reduced pressure. This gave the title compound as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07196107B2 |
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| 出典データセット | uspto-grants-2007_03 |
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| ORD ID | ord-2bba9d4b39564aca80ec509faa4d516e |
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| 出典メモ | uspto-grants-2007_03 |
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