Acetic Acid → 1-Benzyl-4-(4-(pyridin-4-yl)piperazin-1-yl)piperidine-4-carbonitrile

HRID 46002

反応式

HRID 46002 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[CH2:13]([N:20]1[CH2:25][CH2:24][CH2:23][CH2:22][C:21]1=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[C-:27]#[N:28].[K+].CC(O)=O>CO.O>[CH2:13]([N:20]1[CH2:25][CH2:24][C:23]([N:10]2[CH2:9][CH2:8][N:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH2:12][CH2:11]2)([C:27]#[N:28])[CH2:22][CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

7

反応物 4

HCID 176Acetic AcidHCID 9032Potassium CyanideHCID 705171-(4-Pyridyl)piperazineHCID 51700761-Benzyl-2-piperidone

生成物 1

HCID 686295031-Benzyl-4-(4-(pyridin-4-yl)piperazin-1-yl)piperidine-4-carbonitrile収率 47%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A solution containing 1-(pyridin-4-yl)piperazine (58.34 mmol, 1 equiv.), N-benzyl-piperidinone (1 equiv.), KCN (1.1 equiv.), AcOH (3.3 ml) and water (1.3 ml) in methanol was stirred at room temperature for 16 h. The reaction mixture was quenched with NH4OH solution (400 ml) and filtered. The solid precipitate was thoroughly washed with water, dried under vacuum and taken through to the next reaction without further purification. Yield: 47%.

後処理

  1. customThe reaction mixture was quenched with NH4OH solution (400 ml)
  2. filtrationfiltered
  3. washThe solid precipitate was thoroughly washed with water
  4. customdried under vacuum
  5. customtaken through to the next reaction without further purification

出典と根拠

ORDレコード
ord-4fa8de6172fc453393300fd777b7a17a
出典データセット
uspto-grants-2013_09
特許番号
US08541573B2

関連ノート

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