Ethanol → Ethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}acetate

HRID 460025

反応式

HRID 460025 の反応式
C([C:3](Br)([CH2:9][CH3:10])[C:4](=O)[C:5]([O-:7])=[O:6])C.[F:12][C:13]([F:24])([F:23])[C:14]1[CH:22]=[CH:21][C:17]([C:18]([NH2:20])=[S:19])=[CH:16][CH:15]=1.[CH2:25](O)[CH3:26]>>[CH3:10][C:9]1[N:20]=[C:18]([C:17]2[CH:21]=[CH:22][C:14]([C:13]([F:12])([F:23])[F:24])=[CH:15][CH:16]=2)[S:19][C:3]=1[CH2:4][C:5]([O:7][CH2:25][CH3:26])=[O:6]

参加物

4

反応物 3

HCID 702EthanolHCID 27348234-(Trifluoromethyl)thiobenzamideHCID 86592485Ethyl-3-bromooxopentanoate

生成物 1

HCID 17972170Ethyl{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}acetate

実験手順

To a solution of ethyl-3-bromooxopentanoate (O. G. Kulinkovich e.t al., Synthesis, 1986, 378–379) (1.26 g) in absolute ethanol (6 ml) was added 4-(trifluoromethyl)thiobenzamide (1.24 g). The reaction was heated to reflux and stirred at this temperature for 18 hours under nitrogen. The mixture was then allowed to cool to room temperature, prior to cooling in ice. This resulted in crystallization of the product which was filtered and washed with ice cold ethanol to afford the title compound as beige crystals.

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux
  3. temperatureto cooling in ice
  4. customThis resulted in crystallization of the product which
  5. filtrationwas filtered
  6. washwashed with ice cold ethanol

出典と根拠

ORDレコード
ord-e23ffdeada3e44a3a7648acd82a300a3
出典データセット
uspto-grants-2007_03
特許番号
US07196107B2

関連ノート

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