反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([NH2:9])[CH3:8])[CH:2]=1.[CH3:10][O:11][C:12]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[CH:16][C:15]([CH:26]=O)=[CH:14][CH:13]=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClC(Cl)C>[CH3:10][O:11][C:12]1[C:17]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[CH:16][C:15]([CH2:26][NH:9][CH:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[CH3:8])=[CH:14][CH:13]=1参加物
実験手順
1-Pyridin-3-yl-ethylamine (245 mg, 2 mmol) and 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (121 mg, 0.5 mmol) were dissolved in dichloroethane (10 mL). After stirring for 6 h at room temperature, the sodium triacetoxyborohydride (212 mg, 1.0 mmol, Aldrich) was added to the solution at 0 C. The mixture was stirred under nitrogen at room temperature for overnight then the reaction was cooled at ice bath and quenched with saturated aqueous sodium bicarbonate (10 mL). The organic phase was separated and the aqueous phase was extracted with dichloroethane (10 mL×3). The combined organic layers were dried over anhydrous magnesium sulfate and concentrated via vacuo. The crude was purified by column chromatography (silica gel, ethyl acetate) to give the title compound as white solid in 50% yield (87 mg, 0.25 mmol).
後処理
- stirringThe mixture was stirred under nitrogen at room temperature for overnight
- temperaturethe reaction was cooled at ice bath
- customquenched with saturated aqueous sodium bicarbonate (10 mL)
- customThe organic phase was separated
- extractionthe aqueous phase was extracted with dichloroethane (10 mL×3)
- dry with materialThe combined organic layers were dried over anhydrous magnesium sulfate
- concentrationconcentrated via vacuo
- customThe crude was purified by column chromatography (silica gel, ethyl acetate)
出典と根拠
- ORDレコード
- ord-6eb08a0910f14b3eac3200d70a650fab
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07196102B2
関連ノート
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