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1-(Pyridin-4-yl)ethan-1-amine → (6,4'-Dimethoxy-biphenyl-3-ylmethyl)-(1-pyridin-4-yl-ethyl)-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Pyridin-4-yl)ethan-1-amine | HCID 247998 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 反応物 | 6,4'-Dimethoxybiphenyl-3-carbaldehyde | HCID 22391191 | — |
| 反応物 | (6,4'-Dimethoxy-biphenyl-3-ylmethyl)-(1-pyridin-3-yl-ethyl)amine | HCID 22391323 | — |
| 生成物 | (6,4'-Dimethoxy-biphenyl-3-ylmethyl)-(1-pyridin-4-yl-ethyl)-amine | HCID 22391459 | 51% |
反応手順
The title compound was prepared by the same procedure for preparing (6,4′-dimethoxy-biphenyl-3-ylmethyl)-(1-pyridin-3-yl-ethyl)-amine from 1-Pyridin-4-yl-ethylamine (245 mg, 2 mmol), 6,4′-Dimethoxy-biphenyl-3-carbaldehyde (121 mg, 0.5 mmol) and sodium triacetoxyborohydride (212 mg, 1.0 mmol, Aldrich). The title compound was purified by column chromatography (silica gel, ethyl acetate) in form as white solid in 51% yield (89 mg, 0.26 mmol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07196102B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-d4d5ce6d479a4279a77e8d29ae5fc15b |
| 出典メモ | uspto-grants-2007_03 |