1-(Quinolin-4-yl)ethanol → 1-(Quinolin-4-yl)ethan-1-one

HRID 460143ノート

反応式

HRID 460143 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH:11]([OH:13])[CH3:12])=[CH:3][CH:2]=1>ClCCl.[O-2].[Mn+2]>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11](=[O:13])[CH3:12])=[CH:3][CH:2]=1

参加物

4

反応物 1

HCID 53147551-(Quinolin-4-yl)ethanol

生成物 1

HCID 123401901-(Quinolin-4-yl)ethan-1-one収率 100%

試薬・触媒・溶媒 2

HCID 160959Manganese oxide触媒HCID 6344Dichloromethane溶媒

実験手順

To the mixture of manganese oxide (8.69 g, 100 mmol, Aldrich) in dichloromethane (80 mL) was added 1-quinolin-4-yl-ethanol (1.73 g, 10 mmol). The reaction mixture was refluxed for overnight and then cooled to room temperature. The solid was filtered out through Celite pad. The organic solution dried over anhydrous magnesium sulfate and concentrated via vacuo to give crude title compound as light yellow solid in 100% yield (1.71 g, 10.0 mmol).

後処理

  1. temperatureThe reaction mixture was refluxed for overnight
  2. filtrationThe solid was filtered out through Celite pad
  3. dry with materialThe organic solution dried over anhydrous magnesium sulfate
  4. concentrationconcentrated via vacuo

出典と根拠

ORDレコード
ord-7cac8f31b4584785b737b061818ea1a0
出典データセット
uspto-grants-2007_03
特許番号
US07196102B2

反応ノート

読み込み中…