1-(Quinolin-4-yl)ethan-1-one → 1-(1-Methyl-1H-indol-4-yl)ethanone

HRID 460151ノート

反応式

HRID 460151 の反応式
N1C2C(=CC=CC=2)C(C(=O)C)=CC=1.[CH3:14][N:15]1[C:23]2[C:18](=[C:19]([CH:24]([OH:26])[CH3:25])[CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16]1>[O-2].[Mn+2].ClCCl>[CH3:14][N:15]1[C:23]2[C:18](=[C:19]([C:24](=[O:26])[CH3:25])[CH:20]=[CH:21][CH:22]=2)[CH:17]=[CH:16]1

参加物

5

反応物 2

HCID 123401901-(Quinolin-4-yl)ethan-1-oneHCID 223913981-(1-Methyl-1H-indol-4-yl)-ethanol

生成物 1

HCID 149872881-(1-Methyl-1H-indol-4-yl)ethanone

試薬・触媒・溶媒 2

HCID 160959Manganese oxide触媒HCID 6344Dichloromethane溶媒

実験手順

The title compound was prepared by the same procedure for 1-quinolin-4-yl-ethanone from 1-(1-Methyl-1H-indol-4-yl)-ethanol (3.0 g, 17 mmol), manganese oxide (8.69 g, 100 mmol, Aldrich) and dichloromethane (50 mL). The crude title compound was obtained in form as yellow oil in 98% yield (2.9 g, 16.7 mmol).

出典と根拠

ORDレコード
ord-09670b8ea03e4fe19b82605e2f6e6e08
出典データセット
uspto-grants-2007_03
特許番号
US07196102B2

反応ノート

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