Ethyl bromopyruvate → Ethyl 2-aminothiazole-4-carboxylate hydrobromide
反応式
[NH2:1][C:2]([NH2:4])=[S:3].[Br:5][CH2:6][C:7](=O)[C:8]([O:10][CH2:11][CH3:12])=[O:9]>CCO>[BrH:5].[CH2:11]([O:10][C:8]([C:7]1[N:1]=[C:2]([NH2:4])[S:3][CH:6]=1)=[O:9])[CH3:12]参加物
4
反応条件
- 温度
- 45 °C
実験手順
To a stirred suspension of thiourea (24.26 g, 0.319 mol) in 200 proof EtOH (350 mL) at RT, under N2, ethyl bromopyruvate (62.16 g, 0.319 mol) was added dropwise. Upon completion the yellow solution was heated to 45° C. for 15 h, then placed in a fridge overnight. The precipitate was filtered off and washed with cold EtOH (3×100 mL) to yield the title compound as a pale yellow amorphous solid. MS m/z: 173.1 (M+H), 195.1 (M+Na). Calc'd. for C6H9BrN2O2S-253.12.
後処理
- filtrationThe precipitate was filtered off
- washwashed with cold EtOH (3×100 mL)
出典と根拠
- ORDレコード
- ord-f5975fd286cc49ff8034f028dfb50512
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07196104B2
反応ノート
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