Nanofin → [6-(2,6-Dimethyl-piperidin-1-ylmethyl)-pyridin-2-yl]-carbamic acid tert-butyl ester

HRID 460196

反応式

HRID 460196 の反応式
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH3:8])[NH:3]1.[C:9]([O:13][C:14](=[O:24])[NH:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22]Br)[N:17]=1)([CH3:12])([CH3:11])[CH3:10]>CN(C=O)C>[C:9]([O:13][C:14](=[O:24])[NH:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH2:22][N:3]2[CH:4]([CH3:8])[CH2:5][CH2:6][CH2:7][CH:2]2[CH3:1])[N:17]=1)([CH3:12])([CH3:11])[CH3:10]

参加物

4

反応物 2

HCID 68843NanofinHCID 21851763tert-Butyl (6-(bromomethyl)pyridin-2-yl)carbamate

生成物 1

HCID 69411885[6-(2,6-Dimethyl-piperidin-1-ylmethyl)-pyridin-2-yl]-carbamic acid tert-butyl ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
50 °C

実験手順

2,6-Dimethylpiperidine (0.24 mL, 1.74 mmol) was added to a solution of (6-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester (250 mg, 0.87 mmol) in DMF (10 mL) followed by heating at 50° C. and the resulting mixture was stirred for 18 h. The resulting mixture was partitioned between water (10 mL) and CHCl3 (20 mL). The organic layer was washed with H3O, brine, and dried over MgSO4. Concentration in vacuo gave a pale yellow solid. MS m/z: 320.3 (M+H). Calc'd. for C18H29N3O2-319.23.

後処理

  1. customThe resulting mixture was partitioned between water (10 mL) and CHCl3 (20 mL)
  2. washThe organic layer was washed with H3O, brine
  3. dry with materialdried over MgSO4
  4. concentrationConcentration in vacuo
  5. customgave a pale yellow solid

出典と根拠

ORDレコード
ord-3fc3ef085f324258a1fb269005bd6d96
出典データセット
uspto-grants-2007_03
特許番号
US07196104B2

関連ノート

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