Sodium Bromide → Ethyl 2-bromo-1,3-thiazole-4-carboxylate

To a stirred mixture of 2-amino-thiazole-4-carboxylic acid ethyl ester hydrobromide (10 g, 58 mmol), CuSO4 (26.9 g, 168 mmol) and NaBr (22.7 g, 221 mmol) in 9M H4SO4 (aq) (120 mL) at −5° C.−0° C., a pre-cooled solution of NaNO2 (4.4 g, 64 mmol) in H2O (40 mL) was added at such a rate to maintain the temperature at or below 0° C. After complete addition the mixture was maintained at 0° C. for another 30 min then warmed to RT over 2.5 h. The reaction mixture was diluted with H2O (120 mL) and extracted with Et2O (3×100 mL). The aqueous layer was separated, basified to pH 12 with 5N NaOH (aq), then extracted with Et2O (2×100 mL). The organic layers were combined, dried over Na2SO4, filtered and the solvent evaporated in vacuo. The residue was purified by flash chromatography on silica gel (1:9, EtOAc:hexane) to yield the title compound as a white amorphous solid. MS m/z: 235.8, 237.8 (M+H). Calc'd. for C6H6BrNO2S-234.93.

1. temperatureto maintain the temperature at or below 0° C
2. additionAfter complete addition the mixture
3. temperaturethen warmed to RT over 2.5 h
4. extractionextracted with Et2O (3×100 mL)
5. customThe aqueous layer was separated
6. extractionextracted with Et2O (2×100 mL)
7. dry with materialdried over Na2SO4
8. filtrationfiltered
9. customthe solvent evaporated in vacuo
10. customThe residue was purified by flash chromatography on silica gel (1:9, EtOAc:hexane)

ORDレコード

ord-09c48977aaf044cca773bc8a244988ce

出典データセット

uspto-grants-2007_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07196104B2