Hydrochloric Acid → 2-Cyclopropyl-1,3-thiazole-4-carboxylic acid
反応式
[CH:1]1([C:4]2[S:5][CH:6]=[C:7]([C:9]([O:11]CC)=[O:10])[N:8]=2)[CH2:3][CH2:2]1.Cl>C1COCC1.CO.O>[CH:1]1([C:4]2[S:5][CH:6]=[C:7]([C:9]([OH:11])=[O:10])[N:8]=2)[CH2:2][CH2:3]1参加物
4
実験手順
To a mixture of ethyl 2-cyclopropyl-thiazole-4-carboxylate (0.443 g, 2.249 mmol) and LiOH monohydrate (0.472 g, 11.243 mmol) was added a mixture of THF/MeOH/H2O (3:1:1, 50 mL). The reaction was stirred at RT for 24 h. The solution was acidified by addition of conc. HCl (0.1 mL) and the volatiles were removed. Remaining aqueous solution was extracted with EtOAc (3×20 mL). The combined organic layers were dried over Na2SO4 and evaporated to dryness. MS m/z: 169.9 (M+H) Calc'd. for C7H7NO2S-170.0.
後処理
- additionwas added
- customthe volatiles were removed
- extractionRemaining aqueous solution was extracted with EtOAc (3×20 mL)
- dry with materialThe combined organic layers were dried over Na2SO4
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-f8408776d12a47f19772f57013c5cee6
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07196104B2
反応ノート
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