Ammonium Chloride → 1-(7-Bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-ol

HRID 460309

反応式

HRID 460309 の反応式
[Br:1][C:2]1[C:7]2[O:8][CH2:9][O:10][C:6]=2[CH:5]=[C:4]([CH:11]=[O:12])[CH:3]=1.[CH:13]([Mg]Cl)([CH3:15])[CH3:14].[Cl-].[NH4+]>CCOCC>[Br:1][C:2]1[C:7]2[O:8][CH2:9][O:10][C:6]=2[CH:5]=[C:4]([CH:11]([OH:12])[CH:13]([CH3:15])[CH3:14])[CH:3]=1

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 23202437-Bromo-1,3-dioxaindane-5-carbaldehydeHCID 178418918HCID 178418918、化合物

生成物 1

HCID 184453941-(7-Bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-ol収率 96.4%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 7-bromo-benzo[1,3]dioxole-5-carbaldehyde (437 mg, 1.91 mmol) in dry ether (6 mL) was added slowly under argon at −30° C. isopropylmagnesium chloride (1.15 mL, 2.0 M in ether, 2.29 mmol) and the solution stirred for 30 minute. A solution of aqueous ammonium chloride was added and the layers separated. The aqueous layer was extrated with ethyl acetate and the organic combined and washed with water, brine, dried (MgSO4), filtered and evaporated to give 503 mg of 1-(7-bromo-benzo[1,3]dioxol-5-yl)-2-methyl-propan-1-ol.

後処理

  1. customthe layers separated
  2. washwashed with water, brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customevaporated

出典と根拠

ORDレコード
ord-2cb68651744b4569b1e4bc0ac9ee3e60
出典データセット
uspto-grants-2007_03
特許番号
US07196108B2

関連ノート

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