Hydrochloric Acid → 5-(3-Aminothiophen-2-yl)-3H-[1,3,4]oxadiazol-2-one hydrochloride
反応式
[O:1]=[C:2]1[O:6][C:5]([C:7]2[S:8][CH:9]=[CH:10][C:11]=2[NH:12]C(=O)OC(C)(C)C)=[N:4][NH:3]1.[ClH:20]>O1CCOCC1>[ClH:20].[NH2:12][C:11]1[CH:10]=[CH:9][S:8][C:7]=1[C:5]1[O:6][C:2](=[O:1])[NH:3][N:4]=1参加物
4
実験手順
The mixture consisting of 100 mg of tert-butyl [2-(5-oxo-4,5-dihydro[1,3,4]oxadiazol-2-yl)thiophen-3-yl]carbamate and 5 ml of a 4 molar HCl solution in dioxane is stirred for one hour. Afterwards, the volatile fractions are removed under reduced pressure and the residue is stirred with 5 ml of tert-butyl methyl ether and the product is filtered off with suction and dried under reduced pressure.
後処理
- customAfterwards, the volatile fractions are removed under reduced pressure
- stirringthe residue is stirred with 5 ml of tert-butyl methyl ether
- filtrationthe product is filtered off with suction
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-8475ffae7edb463ca082a53f4072f3bc
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07196114B2
反応ノート
読み込み中…