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Diphenyl carbonate → N-[2-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diphenyl carbonate | HCID 7597 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 2-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]-1-propanamine | HCID 13790609 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-[2-Methyl-3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carboxamide | HCID 13657331 | — |
反応手順
2.2 g (8 mmol) of 2-methyl-3-[3-(1-piperidinylmethyl)phenoxy]-1-propanamine in 20 ml of ethanol are stirred together with 1.9 g (8 mmol) of diphenylcarbonate at room temperature for 12 hours. 4 g of hydrazine hydrate is then added to the solution and the reaction mixture is heated under reflux for one hour. Isolation of the product is carried out as described in Example 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04727081 |
| 出典データセット | uspto-grants-1988_02 |
| ORD ID | ord-1a0aab0702614837a64963489ec21c3d |
| 出典メモ | uspto-grants-1988_02 |