関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Iodopropane | HCID 33643 | — |
| 反応物 | Dicyclohexano-18-crown-6 | HCID 85955 | — |
| 反応物 | Potassium Bicarbonate | HCID 516893 | — |
| 反応物 | HCID 178500329 | HCID 178500329 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-[[1-phenyl-2-propylmercapto-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester | HCID 10223420 | — |
反応手順
100 mg of 6-[[2-mercapto-1-phenyl-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester was dissolved in 2 ml of N,N-dimethylformamide, mixed with 40 μl of propyl iodide, 57 mg of potassium hydrogen carbonate and 10 mg of dicyclohexano-18-crown-6, and the mixture was stirred for 15 hours at 20° C. It was filtered, and the filtrate was concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 103 mg was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07196202B2 |
|---|
| 出典データセット | uspto-grants-2007_03 |
|---|
| ORD ID | ord-923e059eb93b4150b12b242d824ebaef |
|---|
| 出典メモ | uspto-grants-2007_03 |
|---|
