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HRID 460515作成日：2026年10月27日
1-Iodopropane → 6-[[1-(4-Methylphenyl)-2-propylmercapto-1H-benzimidazol-6-yl]oxy]Hexanoic Acid Methyl Ester
https://huagongshe.com/reaction/460515
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Iodopropane | HCID 33643 | — |
| 反応物 | Dicyclohexano-18-crown-6 | HCID 85955 | — |
| 反応物 | Potassium Bicarbonate | HCID 516893 | — |
| 反応物 | HCID 178500330 | HCID 178500330 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-[[1-(4-Methylphenyl)-2-propylmercapto-1H-benzimidazol-6-yl]oxy]Hexanoic Acid Methyl Ester | HCID 10296077 | — |
反応手順
1 g of 6-[[2-mercapto-1-(4-methylphenyl)-1H-benzimidazol-6-yl]oxy]hexanoic acid methyl ester was dissolved in 15 ml of N,N-dimethylformamide, mixed with 0.3 ml of propyl iodide, 0.55 g of potassium hydrogen carbonate and 97 mg of dicyclohexano-18-crown-6, and the mixture was stirred for 48 hours at 20° C. It was filtered, and the filtrate was concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 1.06 g was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07196202B2 |
|---|
| 出典データセット | uspto-grants-2007_03 |
|---|
| ORD ID | ord-9ee6b961d3cb4359b6422ba934287ffa |
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| 出典メモ | uspto-grants-2007_03 |
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