Benzyl Bromide → 6-[(2-Benzylmercapto-1-phenyl-1H-benzimidazol-6-yl)oxy]Hexanoic Acid Methyl Ester

HRID 460540

反応式

HRID 460540 の反応式
[CH3:1][O:2][C:3](=[O:26])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16]([SH:18])[N:15]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:14]=2[CH:25]=1.[CH2:27](Br)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1.C(=O)(O)[O-].[K+].C1CC2OCCOCCOC3C(OCCOCCOC2CC1)CCCC3>CN(C)C=O>[CH3:1][O:2][C:3](=[O:26])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[C:16]([S:18][CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[N:15]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)[C:14]=2[CH:25]=1

参加物

6

反応物 4

HCID 7498Benzyl BromideHCID 85955Dicyclohexano-18-crown-6HCID 516893Potassium BicarbonateHCID 178500329HCID 178500329、化合物

生成物 1

HCID 694316006-[(2-Benzylmercapto-1-phenyl-1H-benzimidazol-6-yl)oxy]Hexanoic Acid Methyl Ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
20 °C

実験手順

490 mg of 6-[(2-mercapto-1-phenyl-1H-benzimidazol-6-yl)oxy]hexanoic acid methyl ester was dissolved in 7 ml of N,N-dimethylformamide, mixed with 0.19 ml of benzyl bromide, 278 mg of potassium bicarbonate and 49 mg of dicyclohexano-18-crown-6, and the mixture was stirred for 15 hours at 20° C. It was filtered, and the filtrate was concentrated by evaporation in a vacuum. The residue was purified by column chromatography on silica gel. 548 mg was obtained.

後処理

  1. filtrationIt was filtered
  2. concentrationthe filtrate was concentrated by evaporation in a vacuum
  3. customThe residue was purified by column chromatography on silica gel
  4. custom548 mg was obtained

出典と根拠

ORDレコード
ord-8abc5b1a4f2148129202671593cb4dc2
出典データセット
uspto-grants-2007_03
特許番号
US07196202B2

関連ノート

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