Potassium Carbonate → HCID 18446016、化合物

HRID 460546ノート

反応式

HRID 460546 の反応式
[OH:1][C:2]1[C:10]2[CH:9]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.S(C1C=CC([N+]([O-])=O)=CC=1)(O[CH2:19][C@H:20]1[O:22][CH2:21]1)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH2:19]([O:1][C:2]1[C:10]2[CH:9]=[C:8]([C:11]([O:13][CH3:14])=[O:12])[O:7][C:6]=2[CH:5]=[CH:4][CH:3]=1)[C@H:20]1[O:22][CH2:21]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 10868995(S)-(+)-Glycidyl-4-nitrobenzoateHCID 14494065Methyl 4-hydroxybenzofuran-2-carboxylate

生成物 1

HCID 18446016HCID 18446016、化合物収率 88.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution (60 ml) of methyl 4-hydroxybenzo(b)furan-2-carboxylate (3.6 g) in DMF were added (S)-glycidyl nosylate (5.1 g) and potassium carbonate (6.5 g) and the mixture was stirred at room temperature for 8 hr. The reaction mixture was concentrated under reduced pressure and ethyl acetate was added to the residue. The mixture was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (4.1 g) as a yellow crystalline compound.

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure and ethyl acetate
  2. additionwas added to the residue
  3. washThe mixture was washed with water
  4. dry with materialdried over anhydrous magnesium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-9ce58651bbb2473997b778ccb0267d73
出典データセット
uspto-grants-2007_03
特許番号
US07196199B2

反応ノート

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