Water → 4-(8-hydroxy-2H-chromen-3-ylcarbonyl)morpholine

HRID 460548ノート

反応式

HRID 460548 の反応式
C[O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[O:11][CH2:10][C:9]([C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:14])=[CH:8]2.B(Br)(Br)Br.O>C(Cl)Cl>[OH:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[O:11][CH2:10][C:9]([C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:14])=[CH:8]2

参加物

5

反応物 3

HCID 962WaterHCID 25134Boron tribromideHCID 107548644-(8-methoxy-2H-chromen-3-ylcarbonyl)morpholine

生成物 1

HCID 105633504-(8-hydroxy-2H-chromen-3-ylcarbonyl)morpholine収率 99.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution (70 ml) of 4-(8-methoxy-2H-chromen-3-ylcarbonyl)morpholine (3.5 g) in methylene chloride was added dropwise boron tribromide (9.5 g) at −78° C. The reaction temperature was set to room temperature and the mixture was stirred for 2 hr. The reaction mixture was poured into water and stirred for 1 hr. The organic layer was separated and washed with water and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (3.3 g) as brown crystals.

後処理

  1. customwas set to room temperature
  2. stirringstirred for 1 hr
  3. customThe organic layer was separated
  4. washwashed with water
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-59d077f9f5c044e7af2e0266a3a9785e
出典データセット
uspto-grants-2007_03
特許番号
US07196199B2

反応ノート

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