Methanesulfonic Acid → HCID 22729310、化合物
反応式
[CH3:1][O:2][C:3]1[C:11]2[CH:10]=[C:9]([C:12]([NH:14][NH:15][C:16](=O)[CH3:17])=[S:13])[O:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.CS(O)(=O)=O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:11]2[CH:10]=[C:9]([C:12]3[S:13][C:16]([CH3:17])=[N:15][N:14]=3)[O:8][C:7]=2[CH:6]=[CH:5][CH:4]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a solution (50 ml) of N′-(4-methoxybenzo(b)furan-2-ylthiocarbonyl)acetohydrazide (1.1 g) in toluene was added methanesulfonic acid (1.0 ml) and the mixture was stirred at 80° C. for 30 min. The reaction mixture was concentrated under reduced pressure and the residue was dissolved in ethyl acetate and aqueous potassium carbonate solution, followed by partitioning. After washing with water, the organic layer was dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure to give the title compound (0.82 g) as yellow crystals.