4-(6-Methoxynaphthalen-2-YL)piperidine → (S)-alpha-(2'-(2-hydroxy-3-(4-(6-methoxynaphthalen-2-yl) piperidino) propyloxy) benzylidene)-gamma-butyrolactone
反応式
[O:1]1[CH2:18][C@H:2]1[CH2:3][O:4][C:5]1[CH:17]=[CH:16][CH:15]=[CH:14][C:6]=1[CH:7]=[C:8]1[CH2:13][CH2:12][O:11][C:9]1=[O:10].[CH3:19][O:20][C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[CH:27]=[C:26]([CH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1)[CH:25]=[CH:24]2>CO>[OH:1][C@@H:2]([CH2:18][N:34]1[CH2:33][CH2:32][CH:31]([C:26]2[CH:25]=[CH:24][C:23]3[C:28](=[CH:29][CH:30]=[C:21]([O:20][CH3:19])[CH:22]=3)[CH:27]=2)[CH2:36][CH2:35]1)[CH2:3][O:4][C:5]1[CH:17]=[CH:16][CH:15]=[CH:14][C:6]=1[CH:7]=[C:8]1[CH2:13][CH2:12][O:11][C:9]1=[O:10]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
(S)-α-(2′-(2,3-Epoxypropan-1-yloxy)benzylidene)-γ-butyrolactone (1.2 g) and 4-(6-methoxynaphthalen-2-yl)piperidine (1.2 g) were dissolved in methanol (50 ml), and the mixture was refluxed under heating for 2 hr. After cooling, the solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (chloroform/methanol) to give the title compound (1.0 g), melting point 148–150° C.