Phosphorus tribromide → HCID 22759278、化合物

HRID 460845ノート

反応式

HRID 460845 の反応式
P(Br)(Br)[Br:2].[C:5]([O:8][CH:9]([CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)[C:10]#[C:11][CH2:12]O)(=[O:7])[CH3:6]>CCOCC>[C:5]([O:8][CH:9]([CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)[C:10]#[C:11][CH2:12][Br:2])(=[O:7])[CH3:6]

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 22759281HCID 22759281、化合物

生成物 1

HCID 22759278HCID 22759278、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

Phosphorus tribromide (10.6 g., 0.039 mole) is added dropwise during 15 minutes to a solution of 4-acetoxy-5-(4-fluorophenoxy)-2-pentyn-1-ol (25.1 g., 0.10 mole) in ether (80 ml.). The resulting solution is stirred at room temperature for 1 hour and then heated at reflux for 30 minutes. The solution is poured into 100 ml. of ice water. The organic layer is separated, washed with water and dried over Na2SO4. The solvent is evaporated under reduced pressure to leave the title compound as a light yellow oil.

後処理

  1. temperatureheated
  2. temperatureat reflux for 30 minutes
  3. additionThe solution is poured into 100 ml
  4. customThe organic layer is separated
  5. washwashed with water
  6. dry with materialdried over Na2SO4
  7. customThe solvent is evaporated under reduced pressure

出典と根拠

ORDレコード
ord-9f2a9b2d49534898a3dee23bed80b90a
出典データセット
uspto-grants-1977_12
特許番号
US04061643

反応ノート

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