Acetic Anhydride → HCID 22759330、化合物

HRID 460869ノート

反応式

HRID 460869 の反応式
[C:1]([CH:4]([CH2:14][CH2:15][CH2:16][CH:17]([OH:27])[CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])(=[O:3])[CH3:2].[C:28](OC(=O)C)(=[O:30])[CH3:29]>CCOCC>[C:1]([CH:4]([CH2:14][CH2:15][CH2:16][CH:17]([O:27][C:28](=[O:30])[CH3:29])[CH2:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 22759241HCID 22759241、化合物

生成物 1

HCID 22759330HCID 22759330、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 8-acetyl-12-hydroxy-13-(4-fluorophenoxy)tridecanoic acid (9.5 g., 0.025 mole) and acetic anhydride (6.1 g., 0.06 mole) is heated at 60° for 18 hours. The mixture is then cooled and dissolved in 80 ml. of ether. The solution is extracted with an ice-cold solution of 8 g. of sodium hydroxide in 150 ml. of water. The basic solution is separated and acidified with concentrated hydrochloric acid. The oily acid that separates is taken up in ether, washed with water and dried over sodium sulfate. The ether is evaporated to leave the crude product as a viscous yellow oil.

後処理

  1. temperatureis heated at 60° for 18 hours
  2. temperatureThe mixture is then cooled
  3. dissolutiondissolved in 80 ml
  4. extractionThe solution is extracted with an ice-cold solution of 8 g
  5. customThe basic solution is separated
  6. washwashed with water
  7. dry with materialdried over sodium sulfate
  8. customThe ether is evaporated

出典と根拠

ORDレコード
ord-d32c1d3e80b54578b00476f71cfcbe63
出典データセット
uspto-grants-1977_12
特許番号
US04061643

反応ノート

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