rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochloride → cis-2-Cyclohexylcyclopentylamine hydrochloride

HRID 461036

反応式

HRID 461036 の反応式
[ClH:1].[C:2]1([C@H:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:13])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>O>[ClH:1].[CH:2]1([C@H:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[NH2:13])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

参加物

4

反応物 2

HCID 70051154rac-(1R,2R)-2-phenylcyclopentan-1-amine hydrochlorideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 70050481cis-2-Cyclohexylcyclopentylamine hydrochloride収率 33.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Using rhodium-on-charcoal catalyst in a Paar shaker, 12.6 g of cis-2-phenylcyclopentylamine hydrochloride, M.P. 204°-206° C in 100 ml of water is hydrogenated. In 20 hours when the theoretical amount of hydrogen has been taken up the catalyst is removed by filtration, the filtrate made basic with sodium hydroxide solution, and the resulting precipitate is extracted into ether. After evaporation of the ether the residue is distilled, M.P. 100°-102° C (6.0 mm). The hydrochloride salt is prepared and recrystallized from isopropanol-ether to give 4.4 g of cis-2-(cyclohexyl)cyclopentylamine hydrochloride, M.P 174°-176° C.

後処理

  1. customthe catalyst is removed by filtration
  2. extractionthe resulting precipitate is extracted into ether
  3. customAfter evaporation of the ether the residue
  4. distillationis distilled
  5. customrecrystallized from isopropanol-ether

出典と根拠

ORDレコード
ord-b1ccc48a7cd842fdbd02fff0a3afa683
出典データセット
uspto-grants-1977_12
特許番号
US04061746

関連ノート

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