HCID 11160380、化合物 → 6-Methoxy-2-methyl-2,3-dihydro-1H-inden-1-one

HRID 461097

反応式

HRID 461097 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([CH3:16])[C:11]([O:13]CC)=O)=[CH:5][CH:4]=1>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:6]([CH2:9][CH:10]([CH3:16])[C:11]2=[O:13])=[CH:7][CH:8]=1

参加物

3

反応物 1

HCID 11160380HCID 11160380、化合物

生成物 1

HCID 2311786-Methoxy-2-methyl-2,3-dihydro-1H-inden-1-one

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

Ethyl β-(p-methoxyphenyl)-α-methylpropionate is added to 56 g of polyphosphoric acid with stirring at 50° C. The mixture is then heated to 83°-90° C for two hours. The cooled reaction mixture is poured slowly into a mixture of water and crushed ice with stirring and extracted with 3 × 300 ml of ether. The etheral solution is washed with 10% sodium bicarbonate solution followed by cold water to neutral, then with saturated sodium chloride solution and dried over magnesium sulfate for 1.5 hours and filtered. The solvent is removed on an evaporator and the residue distilled to obtain 6-methoxy-2-methylindanone.

後処理

  1. temperatureThe mixture is then heated to 83°-90° C for two hours
  2. customThe cooled reaction mixture
  3. customcrushed ice
  4. stirringwith stirring
  5. extractionextracted with 3 × 300 ml of ether
  6. washThe etheral solution is washed with 10% sodium bicarbonate solution
  7. dry with materialdried over magnesium sulfate for 1.5 hours
  8. filtrationfiltered
  9. customThe solvent is removed on an evaporator
  10. distillationthe residue distilled

出典と根拠

ORDレコード
ord-4dfc247c4f014ead8560c679c455836a
出典データセット
uspto-grants-1977_12
特許番号
US04061771

関連ノート

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