N,N'-Diethylthiourea → 3-Ethyl-2-ethylimino-4-(4-chloro-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrobromide

HRID 461110

反応式

HRID 461110 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH2:16]([NH:18][C:19]([NH:21][CH2:22][CH3:23])=[S:20])[CH3:17]>CO>[BrH:1].[CH2:22]([N:21]1[C:3]([C:5]2[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=2)([OH:4])[CH2:2][S:20][C:19]1=[N:18][CH2:16][CH3:17])[CH3:23]

参加物

4

反応物 2

HCID 2735009N,N'-DiethylthioureaHCID 12952390Bromo-4'-chloro-3'-sulfamoylacetophenone

生成物 1

HCID 227605773-Ethyl-2-ethylimino-4-(4-chloro-3-sulfamoylphenyl)-1,3-thiazolidine-4-ol-hydrobromide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

To 6.2 g of 2-bromo-4'-chloro-3'-sulfamoylacetophenone 2.2 g of ground 1,3-diethyl-thiourea were added in 40 ml of methanol, the mixture was stirred for 10 minutes at 40° C and for 3 hours at room temperature and the salt was precipitated by adding diethyl ether. After decanting the solvent, the oily product was crystallized with diisopropyl ether heated to 30°-40° C. Colorless crystals melting at 203° C (decomposition).

後処理

  1. customthe salt was precipitated
  2. additionby adding diethyl ether
  3. customAfter decanting the solvent
  4. customthe oily product was crystallized with diisopropyl ether
  5. temperatureheated to 30°-40° C

出典と根拠

ORDレコード
ord-8d2e582d00924b73b31a8dba56531670
出典データセット
uspto-grants-1977_12
特許番号
US04061761

関連ノート

読み込み中…