Sodium Bicarbonate → 4-(4-Chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol

HRID 461115

反応式

HRID 461115 の反応式
Br.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:19])[CH2:13][S:12][C:11](=[N:14][CH:15]([CH3:17])[CH3:16])[N:10]2[CH3:18])=[CH:5][C:4]=1[S:20](=[O:23])(=[O:22])[NH2:21].C(=O)(O)[O-].[Na+]>O>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([OH:19])[CH2:13][S:12][C:11](=[N:14][CH:15]([CH3:17])[CH3:16])[N:10]2[CH3:18])=[CH:5][C:4]=1[S:20](=[O:22])(=[O:23])[NH2:21]

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 227604664-(4-Chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide

生成物 1

HCID 227604674-(4-Chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
40 °C

実験手順

7 g of ground 4-(4-chloro-3-sulfamoylphenyl)-2-isopropylimino-3-methyl-1,3-thiazolidine-4-ol-hydrobromide were dissolved in 80 ml of 40° C hot water and stirred for 30 minutes at 40° C after adding it to a mixture of 60 ml of saturated sodium bicarbonate solution and 100 ml of water. After cooling to room temperature, the mixture was extracted with 200 ml of diethyl ether, the organic phase was dried over sodium sulfate and the solvent was distilled off under reduced pressure. The residue was dissolved in 40 ml of diisopropyl ether and the end product was precipitated by pouring it into 200 ml of stirred petroluem ether.

後処理

  1. additionafter adding it
  2. temperatureAfter cooling to room temperature
  3. extractionthe mixture was extracted with 200 ml of diethyl ether
  4. dry with materialthe organic phase was dried over sodium sulfate
  5. distillationthe solvent was distilled off under reduced pressure
  6. dissolutionThe residue was dissolved in 40 ml of diisopropyl ether
  7. customthe end product was precipitated
  8. additionby pouring it into 200 ml of stirred petroluem ether

出典と根拠

ORDレコード
ord-715146bac3044d5ab2f3833a6eb7a0b8
出典データセット
uspto-grants-1977_12
特許番号
US04061761

関連ノート

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