Dicyclohexylthiourea → 4-(4-Chloro-3-sulfamoylphenyl)-3-cyclohexyl-2-cyclohexylimino-1,3-thiazolidine-4-ol-hydrochloride

HRID 461134

反応式

HRID 461134 の反応式
[Cl:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[C:7]([S:12](=[O:15])(=[O:14])[NH2:13])[CH:6]=1)=[O:4].[CH:16]1([NH:22][C:23]([NH:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[S:24])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[ClH:1].[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2([OH:4])[CH2:2][S:24][C:23](=[N:22][CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[N:25]2[CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:6][C:7]=1[S:12](=[O:15])(=[O:14])[NH2:13]

参加物

3

反応物 2

HCID 727200DicyclohexylthioureaHCID 21316749HCID 21316749、化合物

生成物 1

HCID 227605234-(4-Chloro-3-sulfamoylphenyl)-3-cyclohexyl-2-cyclohexylimino-1,3-thiazolidine-4-ol-hydrochloride

実験手順

5.2 g of 2,4'-dichloro-3'-sulfamoylacetophenone and 4.8 g of 1,3-dicyclohexylthiourea were reacted according to the prescription made in Example 12, the end product was precipitated with 200 ml of diethyl ether and the oil was crystallized after decanting the solvent with diethyl ether. Colorless, crystalline solid body: melting point: 177° C (from acrylonitrile).

後処理

  1. customthe end product was precipitated with 200 ml of diethyl ether
  2. customthe oil was crystallized
  3. customafter decanting the solvent with diethyl ether

出典と根拠

ORDレコード
ord-0cba33b3992a44f6a9575dbd8486e604
出典データセット
uspto-grants-1977_12
特許番号
US04061761

関連ノート

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