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2-Hydroxyacetamide → 2-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Hydroxyacetamide | HCID 69021 | — |
| 反応物 | 2-(4-Chloro-2-methylphenoxy)acetaldehyde | HCID 12391459 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(4-Chloro-2-methylphenoxymethyl)-4-oxazolidinone | HCID 12391492 | 18.2% |
反応手順
A solution containing 4.6 g (0.025 mole) of (4-chloro-2-methylphenoxy)acetaldehyde and 2.1 g (0.028 mole) of glycolamide in 25 ml of tetrahydrofuran and 25 ml of ether was allowed to stand at ambient temperature for 24 hours. The resulting product was washed with 5% sodium carbonate and water, dried and purified by silica chromatography to give 1.1 g of 2-(4-chloro-2-methylphenoxymethyl)-4-oxazolidinone as a white crystalline solid melting at 109°-112°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04062670 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-bd0886031fb84779b40d854807ed63a2 |
| 出典メモ | uspto-grants-1977_12 |