Methanol → 4-(4-n-Hexylpyrimid-2-yl)benzoic acid amide

HRID 461310ノート

反応式

HRID 461310 の反応式
Cl.[C:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH2:11])=[O:10])=[CH:7][CH:6]=1)(=[NH:4])[NH2:3].[CH2:14]([C:20](=[CH:23]OCC)C=O)[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19].[CH3:27][O-].[Na+].CO>CCOCC>[CH2:15]([C:14]1[CH:20]=[CH:23][N:3]=[C:2]([C:5]2[CH:13]=[CH:12][C:8]([C:9]([NH2:11])=[O:10])=[CH:7][CH:6]=2)[N:4]=1)[CH2:16][CH2:17][CH2:18][CH2:19][CH3:27]

参加物

6

反応物 4

HCID 887MethanolHCID 27242934-Amidinobenzamide HydrochlorideHCID 10942334Sodium MethoxideHCID 542364922-n-Hexyl-3-ethoxy-acrolein

生成物 1

HCID 541836714-(4-n-Hexylpyrimid-2-yl)benzoic acid amide

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

0.082 mol of 4-amidino-benzoic acid amide hydrochloride, suspended in a solution of 0.082 mol of 2-n-hexyl-3-ethoxy-acrolein and 0.14 mol of sodium methylate in 150 ml. of methanol, are stirred overnight at room temperature under an atmosphere of nitrogen. The precipitate obtained by diluting the reaction mixture with 3.1 of ether is removed by filtration, washed with water until neutral and dried at 40° in a vacuum drying cabinet, whereby 17.9 g. of 4-(4-n-hexylpyrimid-2-yl)benzoic acid amide are obtained, m.p. 231.6° - 233.0°.

後処理

  1. customThe precipitate obtained
  2. customis removed by filtration
  3. washwashed with water until neutral and
  4. customdried at 40° in a vacuum
  5. customdrying cabinet, whereby 17.9 g

出典と根拠

ORDレコード
ord-2384ed2869fd4d3cb928e419bf92b052
出典データセット
uspto-grants-1977_12
特許番号
US04062798

反応ノート

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