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Hydrogen Bromide → 2-Bromo-5-(trifluoromethyl)benzenamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrogen Bromide | HCID 260 | — |
| 反応物 | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| 反応物 | Bromine | HCID 24408 | — |
| 触媒 | Iron | HCID 23925 | — |
| 生成物 | 2-Bromo-5-(trifluoromethyl)benzenamine | HCID 67989 | — |
反応手順
To 161.0 g of m-aminobenzotrifluoride and 10.0 g of iron filings is added, dropwise, with agitation at 35°-40°, 160.0 g of bromine, using a slow stream of nitrogen to sweep out the evolved hydrogen bromide. Subsequently, the mixture is agitated for an additional 2 hours and then distilled in vacuo to give 4-bromo-3-aminobenzotrifluoride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04062846 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-07101a937af44b0ca9bf8d6e74b4b500 |
| 出典メモ | uspto-grants-1977_12 |