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Triethylamine → 1-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| 反応物 | 1-Isothiocyanato-1,2,3,4-tetrahydronaphthalene | HCID 21393478 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Methoxy-3-(1,2,3,4-tetrahydro-1-naphthyl)-thiourea | HCID 21393496 | — |
反応手順
To an ice-cold, stirred mixture of 0.02 mole of methoxyamine hydrochloride and methylene chloride is added 0.02 mole of triethylamine. The mixture is then allowed to warm to about 15° to 25° C. while a solution of 0.01 mole of 1,2,3,4-tetrahydro-1-naphthyl isothiocyanate in methylene chloride is added dropwise. The mixture is stirred overnight at room temperature and then filtered. The filtrate is washed with water, dried (sodium sulfate), and the solvent evaporated at reduced pressure to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04062856 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-593bab6047ca4353aad3d69cf57c8233 |
| 出典メモ | uspto-grants-1977_12 |