Chlorine → 2,6-Dichloro-4-(dichlorofluoromethyl)pyridine

HRID 461442

反応式

HRID 461442 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8](Cl)([Cl:10])[Cl:9])[CH:5]=[C:4]([Cl:12])[N:3]=1.[Sb](F)(F)[F:14].ClCl>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([Cl:10])([Cl:9])[F:14])[CH:5]=[C:4]([Cl:12])[N:3]=1

参加物

4

反応物 3

HCID 24526ChlorineHCID 24554Antimony trifluorideHCID 897822,6-Dichloro-4-(trichloromethyl)pyridine

生成物 1

HCID 205177022,6-Dichloro-4-(dichlorofluoromethyl)pyridine

実験手順

A mixture containing 138.5 grams (0.522 mole) of 2,6-dichloro-4-(trichloromethyl)pyridine and 34 grams (0.187 mole) of Antimony trifluoride was heated to 80°-84° C. and maintained under agitation for 23 minutes. During this step, a slow stream of chlorine gas was passed over the surface of the reaction mixture. The reaction mixture was steam distilled and the crude 2,6- dichloro-4-(dichlorofluoromethyl)pyridine product was purified by fractionation. The product had a boiling point of 74°-76° C. at 1.0 millimeter of mercury.

後処理

  1. temperaturewas heated to 80°-84° C.
  2. temperaturemaintained under agitation for 23 minutes
  3. distillationdistilled
  4. customthe crude 2,6- dichloro-4-(dichlorofluoromethyl)pyridine product was purified by fractionation

出典と根拠

ORDレコード
ord-de387339e07e463cbf8028122199f01b
出典データセット
uspto-grants-1977_12
特許番号
US04062962

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