2-Acetyl-7-chloro-8-sulfamyl-1,2,3,4-tetrahydroisoquinoline → 7-Chloro-8-sulfamoyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

HRID 461489

反応式

HRID 461489 の反応式
C([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[C:7]([S:15](=[O:18])(=[O:17])[NH2:16])[C:8]([Cl:14])=[CH:9][CH:10]=2)[CH2:5]1)(=O)C>Cl>[ClH:14].[Cl:14][C:8]1[C:7]([S:15](=[O:18])(=[O:17])[NH2:16])=[C:6]2[C:11]([CH2:12][CH2:13][NH:4][CH2:5]2)=[CH:10][CH:9]=1

参加物

3

反応物 1

HCID 213938002-Acetyl-7-chloro-8-sulfamyl-1,2,3,4-tetrahydroisoquinoline

生成物 1

HCID 213938577-Chloro-8-sulfamoyl-1,2,3,4-tetrahydroisoquinoline hydrochloride

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

2-Acetyl-7-chloro-8-sulfamyl-1,2,3,4-tetrahydroisoquinoline is hydrolyzed in refluxing 10% hydrochloric acid (60 ml.) for 2.5 hours. The reaction mixture is evaporated and the residue treated with methanol and ether. The solid is filtered off to give 7-chloro-8-sulfamoyl-1,2,3,4-tetrahydroisoquinoline hydrochloride. The hydrochloride is treated with ammonium hydroxide as in Example 9 to give 7-chloro-8-sulfamoyl-1,2,3,4-tetrahydroisoquinoline.

後処理

  1. customThe reaction mixture is evaporated
  2. additionthe residue treated with methanol and ether
  3. filtrationThe solid is filtered off

出典と根拠

ORDレコード
ord-bdfe5464217b4137a86a885629f1b56c
出典データセット
uspto-grants-1977_12
特許番号
US04062961

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