1,2,3,4-Tetrahydroisoquinolin-8-amine → 8-Sulfamoyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
反応式
NC1C=CC=C2C=1CNCC2.C([N:15]1[CH2:24][CH2:23][C:22]2[C:17](=[C:18]([S:29](=[O:32])(=[O:31])[NH2:30])[C:19]([C:25]([F:28])([F:27])[F:26])=[CH:20][CH:21]=2)[CH2:16]1)(=O)C>>[S:29]([C:18]1[C:19]([C:25]([F:26])([F:28])[F:27])=[CH:20][CH:21]=[C:22]2[C:17]=1[CH2:16][NH:15][CH2:24][CH2:23]2)(=[O:31])(=[O:32])[NH2:30]参加物
3
実験手順
The above prepared 8-amino tetrahydroisoquinoline compound is converted to the corresponding 8-chlorosulfonyl compound and then to the 8-sulfamoyl compound, 2-acetyl-8-sulfamoyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline, by the procedure of Example 15. The acetyl group is removed by acid hydrolysis by the procedure of Example 15 to give 8-sulfamoyl-7-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline.
後処理
- customThe acetyl group is removed by acid hydrolysis by the procedure of Example 15