Potassium Carbonate → 4-(m-Benzoylphenyl)-2-butanone

HRID 461520

反応式

HRID 461520 の反応式
Br[CH2:2][C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:7].[C:17]([CH2:20]C(=O)C)(=[O:19])[CH3:18].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[C:6]([C:5]1[CH:4]=[C:3]([CH2:2][CH2:18][C:17](=[O:19])[CH3:20])[CH:16]=[CH:15][CH:14]=1)(=[O:7])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 31261AcetylacetoneHCID 895863-(Bromomethyl)benzophenone

生成物 1

HCID 204960404-(m-Benzoylphenyl)-2-butanone収率 39.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 3-bromomethylbenzophenone (2.75 g.), acetylacetone (1 g.), potassium carbonate (1.4 g.) and ethanol (50 ml) was refluxed for 2 hours. The solvent was then evaporated and the residue extracted with ether. Distillation of the concentrated extracts gave 4-(m-benzoylphenyl)-2-butanone (1 g.), b.p. 220° C (4 mm). [An alternative preparation of this compound appears in German Offenlegungsschrift No. 2,243,444].

後処理

  1. temperaturewas refluxed for 2 hours
  2. customThe solvent was then evaporated
  3. extractionthe residue extracted with ether
  4. distillationDistillation of the concentrated extracts

出典と根拠

ORDレコード
ord-f75ab447997a45649acb9e00944ff338
出典データセット
uspto-grants-1977_12
特許番号
US04062978

関連ノート

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