4-Chloro-3-nitrobenzophenone → {4-[Methyl(octyl)amino]-3-nitrophenyl}(phenyl)methanone

HRID 461626

反応式

HRID 461626 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1Cl)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8])([O-:3])=[O:2].[CH3:19][NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]>C(O)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1[N:20]([CH3:19])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 417434-Chloro-3-nitrobenzophenoneHCID 75538Octylmethylamine

生成物 1

HCID 23342777{4-[Methyl(octyl)amino]-3-nitrophenyl}(phenyl)methanone

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 9.23 g. of 3-nitro-4-chloro-benzophenone, 10 ml. of ethanol and 10.3 g. of N-methyl-N-octylamine is stirred at 80° to 85° C for 30 minutes, and then the mixture is poured onto 100 ml. of ice water. The aqueous phase is extracted with 2x75 ml. of benzene. The benzene phases are combined, washed with distilled water with chloride-free, dried over anhydrous magnesium sulphate, filtered, and evaporated in vacuo. 11.57 g. of 3-nitro-4-(N-methyl-N-octylamino)-benzophenone are obtained in the form of an oily residue. On the basis of thin layer chromatographical examination, a pure, uniform product is obtained.

後処理

  1. additionA mixture of 9.23 g
  2. additionthe mixture is poured onto 100 ml
  3. extractionThe aqueous phase is extracted with 2x75 ml
  4. washwashed with distilled water with chloride-free
  5. dry with materialdried over anhydrous magnesium sulphate
  6. filtrationfiltered
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-5008c09bbebb4d06a7beba95648bd188
出典データセット
uspto-grants-1977_12
特許番号
US04064121

関連ノート

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