化工社化工社 化学情報印刷レポート · 研究参考用
Orotic Acid → 6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Orotic Acid | HCID 967 | — |
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | Diketene | HCID 12661 | — |
| 反応物 | Chlorine | HCID 24526 | — |
| 反応物 | 4-Chloro-3-oxobutyryl chloride | HCID 3016262 | — |
| 生成物 | 6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione | HCID 73273 | — |
反応手順
German OS No. 2,025,247 teaches that orotic acid can be prepared by converting, in a first stage, diketene and chlorine to γ-chloroacetoacetic acid chloride, in a second stage, reacting the γ-chloroacetoacetic acid chloride with urea to form 6-chloromethyluracil, separating the 6-chloromethyluracil and oxidizing the 6-chloromethyluracil with hydrogen peroxide to orotic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04064126 |
| 出典データセット | uspto-grants-1977_12 |
| ORD ID | ord-1880da1d0333470ab4ae01d8c2a3dee2 |
| 出典メモ | uspto-grants-1977_12 |