Hydrochloric Acid → HCID 178509337、化合物
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH2:20][NH:21]C(=O)OC(C)(C)C)[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]3=[N:17][CH:18]=[CH:19][N:9]23)=[CH:4][CH:3]=1.[ClH:29]>O1CCOCC1>[Cl-:29].[NH2:21][CH2:20][C:8]1([C:5]2[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=2)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]2=[NH+:17][CH:18]=[CH:19][N:9]12参加物
4
実験手順
To a solution of tert-butyl {[5-(4-bromophenyl)-5H-imidazo[2,1-a]isoindol-5-yl]methyl}carbamate (575 mg) in dioxane (2 mL) was added a HCl solution (3.265 mL, 4 M in dioxane) and stirred at room temperature for 1.5 h. After this time 1.5 mL more HCl solution was added and stirring continued for another 3 h. The reaction mixture was then concentrated (azeotroped once from toluene) and dried under vacuum to give title compound as a white solid. Mass. found (M+H)+, 342.0.