Dichloroacetyl chloride → Cyclobutanone, 4-chloro-2,2,3,3-tetramethyl-

HRID 461753

反応式

HRID 461753 の反応式
[Cl:1][CH:2](Cl)[C:3](Cl)=[O:4].[CH3:7][C:8](=[C:10]([CH3:12])[CH3:11])[CH3:9]>C(C(CC(C)C)=O)C(C)C.[Zn]>[Cl:1][CH:2]1[C:10]([CH3:12])([CH3:11])[C:8]([CH3:9])([CH3:7])[C:3]1=[O:4]

参加物

5

反応物 2

HCID 6593Dichloroacetyl chlorideHCID 112502,3-Dimethyl-2-butene

生成物 1

HCID 11105656Cyclobutanone, 4-chloro-2,2,3,3-tetramethyl-

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 7958Isobutyl ketone溶媒

実験手順

This process is described in U.S. Pat. No. 4,028,418 Gradual addition of dichloroacetyl chloride to a stirred solution of 2,3-dimethyl-2-butene in diisobutyl ketone containing suspended zinc particles resulted in a yield of 2-chloro-3,3,4,4- tetramethylcyclobutanone of 75%, calculated on starting dichloroacetyl chloride of 3.9, a molar ratio of dichloroacetyl chloride to 2,3-dimethyl-2-butene of 1.3, a temperature of 43° C, zinc in the form of turnings having a largest dimension of 0.841 mm and a starting concentration of 2,3-dimethyl-2-butene of 2.4 mol per liter of diisobutyl ketone. Modifying this experiment by reducing the molar ratio of zinc to dichloroacetyl chloride to 1.1 resulted in a decrease in yield to 51%, the theoretical yield still being 77.4% cf. Example VIII of U.S. Pat. No. 4,028,418.

出典と根拠

ORDレコード
ord-35a7febe94054baca872a07bc17841a0
出典データセット
uspto-grants-1977_12
特許番号
US04064174

関連ノート

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